產品詳情
Cat#：183P12
序列（三字母）：H-Lys-psi(CH?NH)Lys-Pro-Tyr-Ile-Leu-OH
序列（單字母）：K-psi(CH?NH)KPYIL
類似名：JMV 449, (Lys8-acetyl-Lys9)-Neurotensin (8-13)
分子式：C??H??N?O?
分子量：746.99
CAS#：139026-66-7
合成方法：Synthetic
存儲條件：-20 ± 5 °C
應用：Cancer Research
描述：Replacement of the Lys?-Lys? peptide bond by the CH?NH bond produced an analog with quite interesting pharmacological properties. The degradation-resistant peptide analog Lys-psi(CH2NH)Lys-Pro-Tyr-Ile-Leu (JMV-449) was the most active in the binding and biological assays. JMV-449 exhibited higher binding and biological potencies than neurotensin. JMV449 was also about 10 times more potent than neurotensin (8-13) in the bioassay, whereas both peptides were equipotent in the binding assay.
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